The Evidence · How we grade the science

We grade our own evidence.
Including the gaps.

Most supplement brands cite a mouse study and call it proof. We sort every active into three honest tiers — regulator-authorised, clinically studied, or emerging — and tell you which is which on this page and on every product.

SP-EVIDENCE · Grading

Three tiers. No spin.

The tier tells you how strong the human evidence is — not how excited we are about the ingredient.

ESTABLISHED

Authorised claims

Effects assessed and authorised on the GB Nutrition & Health Claims register. These are the only statements we make as claims — and only at the doses the authorisation requires.

CLINICALLY STUDIED

Human trials, no authorised claim

Randomised human trials exist — sometimes good ones — but no claim has been authorised. We describe the research; we don't promise the result.

EMERGING

Early or mixed

Small studies, mixed findings, or evidence mainly in specific groups. We say so plainly. If an ingredient lives here, you'll know before you buy.

Daily

The base layer has the strongest evidence in the range — which is exactly why it's the base.

Vitamin D3

ESTABLISHED
ESTABLISHED · AUTHORISED CLAIMS

Vitamin D contributes to the normal function of the immune system, the maintenance of normal bones and muscle function, and normal absorption of calcium — all authorised claims.

Our position: Government advice is that everyone should consider a daily vitamin D supplement during autumn and winter, because sunlight at UK latitudes is too weak for the skin to make enough.

Sources: GB NHC register (vitamin D entries) · NHS / SACN vitamin D guidance (10µg daily, Oct–Mar)

Magnesium

ESTABLISHED
ESTABLISHED · AUTHORISED CLAIMS

Magnesium contributes to a reduction of tiredness and fatigue, normal functioning of the nervous system, normal muscle function and normal psychological function — authorised claims.

Our position: We use the citrate form for its solubility; the claims attach to magnesium itself, at meaningful doses, which is why the amount is on the front of the pack.

Sources: GB NHC register (magnesium entries)

Omega-3 (EPA & DHA)

ESTABLISHED
ESTABLISHED FOR FUNCTION · HONEST ON OUTCOMES

EPA and DHA contribute to the normal function of the heart at an intake of 250 mg per day, and DHA contributes to maintenance of normal brain function and vision at 250 mg per day — authorised claims, with the thresholds stated.

Our position: A major Cochrane review found that omega-3 supplements make little or no difference to the risk of cardiovascular events like heart attacks in the general population. Function claims and disease prevention are different things, and we won't blur them. If EPA+DHA from a product is below 250 mg/day, we don't make the heart claim at all.

Sources: GB NHC register (EPA/DHA entries) · Abdelhamid et al., Cochrane Database Syst Rev 2018

Joints

The category where honesty matters most — because the marketing usually runs furthest ahead of the data.

Glucosamine

CLINICALLY STUDIED
CLINICALLY STUDIED · NO AUTHORISED CLAIM

One of the most-trialled supplements in existence — including GAIT, a large NIH-funded randomised trial. Overall results were mixed: no significant benefit over placebo for the whole study population, with exploratory signals in a subgroup with moderate-to-severe pain.

Our position: No authorised claim exists and we make none. We state the dose (1500 mg, the amount used in trials) and let you run your own n-of-1.

Sources: Clegg et al., NEJM 2006 (GAIT) · EFSA opinions on glucosamine

Curcumin + Piperine

CLINICALLY STUDIED
CLINICALLY STUDIED · FORMULATION-LED

Curcumin is poorly absorbed on its own. The reason black pepper is in the capsule is a specific pharmacokinetic finding: piperine increased curcumin bioavailability by roughly 2,000% in a human crossover study.

Our position: Joint claims for turmeric are not authorised, so we don't make them. What we stand behind is the formulation logic — if you take curcumin at all, take it in a form your body can absorb.

Sources: Shoba et al., Planta Medica 1998

Sleep

No sedatives — actives with human data on sleep quality and the wind-down.

Montmorency Cherry

CLINICALLY STUDIED
CLINICALLY STUDIED · SMALL TRIALS

Tart Montmorency cherries naturally contain melatonin. In a placebo-controlled crossover trial, tart cherry concentrate raised urinary melatonin and modestly improved total sleep time and sleep efficiency in healthy adults.

Our position: The trials are small and the effects are modest — minutes, not hours. Worth having before bed, but you should know the size of the effect you're buying.

Sources: Howatson et al., European Journal of Nutrition 2012

Magnesium (evening)

EMERGING
ESTABLISHED FOR FATIGUE · EMERGING FOR SLEEP

The authorised claims — reduction of tiredness and fatigue, normal nervous-system and psychological function — are the basis for magnesium's place in the evening slot.

Our position: Direct evidence that magnesium improves sleep in people who aren't deficient is limited and mixed. “Magnesium fixes sleep” is internet folklore we won't repeat.

Sources: GB NHC register (magnesium) · systematic reviews of magnesium & sleep (evidence graded low)

Skin

Hydrolysed Collagen

CLINICALLY STUDIED
CLINICALLY STUDIED · NO AUTHORISED CLAIM

Randomised, placebo-controlled trials of collagen peptides at 2.5–10 g daily have reported measurable improvements in skin elasticity in women over 35 after 4–8 weeks. No claim is authorised, so we describe the studies rather than promise the mirror.

Our position: Our powder supplies 10,000 mg — the top of the studied range — because an under-dosed collagen product is a flavoured drink.

Sources: Proksch et al., Skin Pharmacology & Physiology 2014

Vitamin C — the pairing

ESTABLISHED
ESTABLISHED · AUTHORISED CLAIM

Vitamin C contributes to normal collagen formation for the normal function of skin, cartilage, bones, gums and teeth — an authorised claim, and the reason the protocol pairs your collagen with your morning vitamin C.

Our position: This is our only deliberate stack — one authorised mechanism, two products, stated plainly.

Sources: GB NHC register (vitamin C — collagen formation entries)

Mind

Lutein + Zeaxanthin

CLINICALLY STUDIED
CLINICALLY STUDIED · LANDMARK TRIAL, SPECIFIC GROUP

The carotenoids your macula is made of. In AREDS2 — a large randomised trial run by the US National Eye Institute — lutein and zeaxanthin were studied as part of a formulation in people with age-related macular degeneration, where they proved a safer substitute for beta-carotene.

Our position: Evidence in a specific clinical population, not a general “eye health” promise — and no claim is authorised for the general population.

Sources: AREDS2 Research Group, JAMA 2013

DHA

ESTABLISHED
ESTABLISHED · AUTHORISED AT THRESHOLD

DHA contributes to maintenance of normal brain function and normal vision at 250 mg per day — authorised claims with a stated threshold.

Our position: A capsule with 60 mg of DHA can't honestly carry a brain claim. Ours print the per-capsule DHA so you can do the arithmetic yourself.

Sources: GB NHC register (DHA entries)

Gut & Immunity

Live Cultures

EMERGING
EMERGING · STRAIN-SPECIFIC SCIENCE

Gut microbiome science is real and moving fast — but benefits are strain-specific and most general “gut health” marketing outruns the data. UK rules treat the word “probiotic” itself as an implied health claim, which is why our labels say live cultures and state the strains and count instead.

Our position: We tell you the strains, the count at end of shelf life, and stop there.

Sources: GB/EU guidance on “probiotic” as an implied claim · strain-level literature varies by product

Vitamin C & Zinc

ESTABLISHED
ESTABLISHED · AUTHORISED CLAIMS

Vitamin C and zinc each contribute to the normal function of the immune system, and vitamin C additionally to the reduction of tiredness and fatigue — authorised claims and the backbone of the Immunity module.

Our position: What we won't say: that anything in this range prevents colds or flu. Immune function support is the authorised claim; prevention is not.

Sources: GB NHC register (vitamin C, zinc entries)
SP-EVIDENCE · Standards

Our research standards.

Five rules every word on this site has to pass.

RULE 01

Human data or it doesn't count.

Cell and animal studies inform formulation; they never appear as evidence of what a product does for you.

RULE 02

Claims only when authorised.

If it isn't on the GB Nutrition & Health Claims register, we describe the research neutrally — we don't promise the outcome.

RULE 03

Doses match the studies.

If the trials used 1500 mg, the product supplies 1500 mg. An active at a token dose is decoration, and we don't sell decoration.

RULE 04

Thresholds are printed.

Where a claim only applies above an intake (250 mg EPA+DHA for the heart claim), the threshold appears next to the claim.

RULE 05

Negative findings stay on the page.

When a major review is unflattering — like Cochrane on omega-3 and cardiovascular events — it's cited here, not buried.

ALWAYS

Supplements supplement.

Nothing here replaces a varied diet, sleep, or movement — and nothing here treats or prevents disease.

References on this page are provided for transparency and education. Food supplements are not a substitute for a varied, balanced diet and a healthy lifestyle. Do not exceed stated doses. If you are pregnant, breastfeeding, taking medication (including anticoagulants) or under medical supervision, consult a doctor or pharmacist before use. Nothing on this page constitutes medical advice, and no product is intended to diagnose, treat, cure or prevent any disease.